The San Francisco 49ers announced that Dr. Harry Edwards has been named as the team’s 2024 Inspire Change Changemaker.

The Los Angeles Rams hope to come away with the same result tonight as they had in Week 3 when they hosted the San Francisco ...

SportsLine's team of Vegas experts, NFL model, and AI PickBot just revealed the top 49ers vs. Rams NFL betting preview ...

SportsLine's NFL model locked in its Thursday Night Football NFL anytime touchdown picks for Los Angeles Rams vs. San ...

Sunday night as snow fell throughout Buffalo’s Week 13 home game against San Francisco. For the Bills, the conditions were ...

Now, the San Francisco 49ers are headed to Lambeau, fresh off a last-second defeat at the hands of the Seattle Seahawks. Neither team played their best in Week 11, but only one of them walked away ...

Green Bay Packers coach Matt LaFleur hasn't been able to beat the San Francisco 49ers in the playoffs. Perhaps he'll have better fortune against Kyle Shanahan in the regular season. After a 2-2 ...

SANTA CLARA, Calif. -- On an already lengthy injury list full of some of the biggest names on the team, the San Francisco 49ers had another significant addition Monday: quarterback Brock Purdy.

Oh look, it's the San Francisco 49ers again. When the Green Bay Packers meet the 49ers on Sunday, it will mark the latest in a long string of compelling matchups between the two franchises and ...

The San Francisco 49ers have had an up-and-down season thus far. The team sits at a 5-5 record and dropped a close game to the Seattle Seahawks on Sunday, losing with a final 20-17 score.