A 38-year-old man presented with a 15-year history of a waxing and waning rash on his palms and soles. A skin biopsy revealed dense lymphocytic infiltration of the superficial and middle dermis.

In the KEYNOTE-522 trial, neoadjuvant and adjuvant pembrolizumab improved pathological complete response and event-free survival among patients with early-stage triple-negative breast cancer.

Pneumococcal conjugate vaccines are highly effective in reducing vaccine-type pneumococcal disease but are expensive. Fractional-dose vaccines may help sustain vaccine programs. New research ...

Most rotator-cuff tears are degenerative, atraumatic, and more prevalent with age. Nonoperative treatment, including physical ...

Twice-yearly subcutaneous lenacapavir has been shown to be efficacious for prevention of HIV infection in cisgender women. The efficacy of lenacapavir for preexposure prophylaxis (PrEP) in ...

Nivolumab, a PD-1 inhibitor, and ipilimumab, a cytotoxic T-lymphocyte antigen 4 inhibitor, are immune checkpoint inhibitors with complementary mechanisms of action, which might enhance antitumor ...

Of the 153 enrolled patients, 127 (83.0%) received at least one infusion of obe-cel and were evaluable. In cohort 2A (94 patients; median follow-up, 20.3 months), overall remission occurred in 77% ...

Panel A is a map of the communes in Nha Trang showing the trial-group assignment in each commune (no vaccination, 0p+1, 1p+1, 2p+1, or 3p+0). Panel B shows the percentages of infants (children 4 ...

Dr. Lara Basovic: A 41-year-old man was admitted to the epilepsy monitoring unit (EMU) of this hospital because of seizures. When the patient was 4 years of age, his mother noticed an episode of ...

Lactation is essential for life and provides essential nutrients to offspring with benefits for mothers and their progeny. In addition to its nutritional, immunologic, and psychosocial aspects ...

This Double Take video from the New England Journal of Medicine presents the case of a 42-year-old woman presenting with cough, fatigue, fevers, and shortness of breath. Based on a Clinical ...