Values are displayed relative to either codon usage (left) or relative to the input library ... SS, mating factor alpha signal sequence; AS, alanine and serine dipeptide linker; NbGFP, LaG16 anti-GFP ...

The V600E missense mutation in the cytosolic serine–threonine kinase BRAF leads to its constitutive activation (independently of upstream regulation by RAS at the plasma membrane, as shown in ...

Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Unidad de Investigación, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain Instituto de ...

1 Alternative splicing will sometimes introduce a premature stop codon into an mRNA, which NMD will recognize as an mRNA that needs to be degraded. “It's a very common mechanism of downregulation,” ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Aurora-A is an essential cell-cycle kinase ...

siRNA sequences of human FCHO2, Nedd4L, and FBP17 were 5′-CCA CAG AUC UUA GAG UGG AUU AUA A-3′ (corresponding to nucleotides 2048–2072 relative to the start codon), 5′-GAA GAG UUG CUG GUC UGG CCG UAU ...

This study provides valuable insights into how chromatin-bound PfMORC controls gene expression in the asexual blood stage of Plasmodium falciparum. By interacting with key nuclear proteins, PfMORC is ...

Lipodystrophies are rare conditions resulting from disturbances in adipogenesis or lipid storage, culminating in a loss of adipose tissue without nutritional restriction or catabolic state. The ...

The DNA fragment can be put in phase, if this is not already the case, by the addition or subtraction of the appropriate number of nucleotides as well as the addition of a Met initiation codon for the ...

Introduction: Premature and low-birthweight infants are at especially high risk of perinatal complications, including impaired thermoregulation, infections and respiratory distress. Such adverse ...