However, tumor vasculature is abnormal, chaotic and leaky due to the high production of angiogenic factors such as VEGF. In tumors, Dll4/Notch signaling appears to dampen (much like a resistor in ...

The VEGF family members VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F, and PlGF attach in distinct patterns to three related receptor protein tyrosine kinases —VEGFR1/FLT1, VEGFR2/KDR ...