eLife9h
Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies
(f) Acute CDK12 inhibition decreases BRCA2 protein and induces apoptosis after 24h. Western blot of 22Rv1 cells treated 6 ... genes and markers of DNA damage (γH2A.X) and apoptosis (total/cleaved ...
eLife11h
Single cell transcriptomics reveals early photoreceptor states, cell-specific transcript isoforms, and cancer-predisposing features
Here, we used deep full-length single-cell RNA-sequencing to distinguish post-mitotic cone and rod developmental states and cone-specific features that contribute to retinoblastomagenesis. The ...