Last time they played: The 49ers made easy work of the Cardinals in a 45-29 win last ... league’s best head coaches since he took the San Francisco job in 2017. Prior to that, he was an ...

Brandon Staley, the 49ers’ assistant head coach, could leave Kyle Shanahan’s staff. He is likely to be the Saints’ new defensive coordinator under head coach Kellen Moore. If there is any doubt about ...

In the final minutes of the game, two important plays helped the Arizona Cardinals secure a win over the San Francisco 49ers. The forecast for the 1:05 p.m. kickoff at Levi’s Stadium in the San ...

As they often do, the Broncos are expected to play the San Francisco 49ers and Arizona Cardinals in preseason games ahead of the 2025 regular season. Denver is working on scheduling a joint practice ...

The Arizona Cardinals were urged to sign San Francisco 49ers linebacker Dre Greenlaw in free agency this offseason.

To sell San Francisco on moving Samuel within the division, Arizona could make their ... This way if Samuel works out like the Cardinals will hope he does, The 49ers will at least receive better ...

He likely would have surpassed 1,000 receiving yards had he not been ejected from the San Francisco 49ers' season finale against the Arizona Cardinals. 49ers GM John Lynch said the team would like ...

Headlining a list of changes to the San Francisco coaching staff is the long-awaited promotion of Klay Kubiak to offensive ...

The 49ers are in an interesting spot. They're currently scheduled to pick just outside the top 10 in the upcoming NFL Draft, which means they're not assured to get a franchise-changing player.

Deebo Samuel Jr. requested a trade, and it looks like the 49ers will honor his request, according to general manager John ...