A research team have recently published their article, "Rationally designed pooled CRISPRi-seq uncovers an inhibitor of ...

Researchers from the University of Washington are developing new antibiotics targeting bacterial methionyl-tRNA synthetase (MetRS). This enzyme is responsible for charging tRNA(met) with methionine ...

In addition to the urgent need for new antibiotics, alternative strategies are required to tackle the problem of antibiotic resistance. Michaela Wenzel, Associate Professor at Chalmers University of ...

Department of Chemical Engineering, Stanford University, Stanford, California 94305, United States Sarafan ChEM-H, Stanford University, Stanford, California 94305, United States Sarafan ChEM-H, ...

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China University of Chinese Academy of Sciences, Beijing 100049, P. R.

Some of the promising drug candidates in Phase II/III trials include antibodies such as guselkumab (an IL-23 inhibitor by Janssen ... small molecules and antibiotics to provide synergistic treatment ...

However, in PKCλ/ι-deficient cells treated with androgen receptor inhibitors ... They found that inhibiting either protein synthesis or the TGF-β pathway effectively reversed resistance ...

We also prioritized compounds that work differently from existing antibiotics to minimize cross-resistance. Finally, we tested how effectively our inhibitors could overcome antibiotic resistance in E.

These biomolecules, which came to be known as naphthocyclinones, are representative of a family of antibiotics with ... concise strategy toward heterodimer synthesis via the logical design of ...