Moreover, apical–basal polarity integrates intracellular signaling with the microenvironment by regulating metabolic signaling, extracellular matrix remodeling and tissue level organization.

Using a molecular cellular compass, individual cells in complex organisms know which way is up or down, in epithelial cells known as apical-basal polarity. Determining the orientation is essential ...

Group leader Henrik Semb and first author Zara Löf Öhlin. Epithelial cells, which line the surfaces of blood vessels and organs, possess a feature called apicobasal polarity that enables them to ...