eLife21d
Exploring the role of the immune microenvironment in hepatocellular carcinoma: Implications for immunotherapy and drug resistance
Tumor cells secrete sonic hedgehog, driving M2 polarization, and produce CXCL9 and CXCL10, inhibiting CD8 T-cell recruitment ... The latest advancements and strategies in immunotherapy are as follows.
ascopubs.org20d
Checkpoint blockade as neoadjuvant strategy: A single-arm meta-analysis of dual PD-1/PD-L1 and CTLA-4 inhibition in urothelial cancer.
Safety and efficacy of FGFR inhibitors in urothelial carcinoma: A systematic review and meta-analysis. Efficacy and safety of tislelizumab (T) combined with gemcitabine and cisplatin (GC) for patients ...
gut.bmj4d
IDDF2024-ABS-0066 Novel peptides derived from sutterella wadsworthensis potentiating the efficacy of PD-1 blockade on colorectal cancer
Gut microbiota is a critical factor in determining the efficacy of PD-1/L1 blockade. We aimed to explore the role and mechanism of Sutterella wadsworthensis (S.wadsworthensis) in improving the ...
Frontiers21d
AWT020: a novel fusion protein harnessing PD-1 blockade and selective IL-2 Cis-activation for enhanced anti-tumor immunity and diminished toxicity
The improved tolerability of AWT020 facilitates the complete blockade of the PD1-PD-L1 interaction, thereby preventing the inhibitory signal mediated by PD-1. Concurrently, IL-2R is activated to ...
European Medical Journal17d
New Strategy Enhances PD-1 Therapy in Treatment-Resistant Cancers
A new study shows that neutralising GDF-15 restores immune response in advanced cancers resistant to PD-1 blockade.
pharmaphorum3d
Opdivo's subcutaneous PD-1 inhibitor cleared in US
It is the second drug in the PD-1/PD-L1 inhibitor class to be cleared in a subcutaneous injection form by the FDA after Roche's Tecentriq Hybreza (atezolizumab and hyaluronidase) – which got a ...
pharmaphorum5d
MSD joins PD-1/VEGF push in cancer with LaNova deal
There has been a lot of talk about drugs targeting both PD-1 and VEGF stealing the crown held by MSD's Keytruda in cancer immunotherapy. Now, the company has made a move to try to make sure it isn ...
CNN4d
‘They are fighting us through our food’: Gazans face new Israeli aid blockade
US-based group Human Rights Watch warned Thursday that Israel’s blockade would shut down most of the Palestinian territory’s water infrastructure within a week by starving it of fuel.