Preclinical data demonstrate that inhibiting the p300 KAT domain reactivates p53 in HPV-driven tumors resulting in anti-tumor activity - SAN MATEO, Calif., and CAMBRIDGE, Mass., Oct. 23, 2024 (GLOBE ...

Enrollment on track in registrational Phase 2 portion of PYNNACLE clinical trial evaluating rezatapopt as monotherapy in patients with TP53 Y220C ...

However, several limitations for this class of drugs remain. For anti-telomerase drugs to engage p53-dependent apoptotic and/or senescence pathways to suppress tumorigenesis, an intact p53 pathway ...

At this time, membranes were incubated with the following monoclonal antibodies: 5 µg/mL anti-p53 (clone Pab 240), 5 µg/mL antiphospho-p53 (serine 392) [both from Calbiochem-Novabiochem ...

In case you didn’t know, two motor shows are happening simultaneously this week. But before anyone could pull the covers off ...

Data show that p300 KAT inhibitor KB-9558 was highly selective against human papillomavirus (HPV) oncoproteins E6 and E7, and ...

It is with great sadness and heavy heart that we announce the recent passing of Dr. Mikhail (Misha) V. Blagosklonny, our ...

Gemtuzumab ozogamicin, a potent anti-CD33 calicheamicin antibody-drug conjugate (ADC ... SWTX-143 treatment was well tolerated in mice but induced tumor regression in xenograft and Lats1/2;p53 mutant ...

TORONTO, Oct. 21, 2024 (GLOBE NEWSWIRE) -- ASUS today announces that the ExpertBook P5 (P5405), a groundbreaking Copilot+ PC ...

A wave of high-profile hate crimes at the beginning of the COVID-19 pandemic drew national ire over anti-Asian attacks. But the new survey, shared exclusively with USA TODAY, shows that the Asian ...

Wednesday, we learned why. Anti-DEI backlash has sent the company spinning. The Paris-based video game publisher pushed the release of its biggest game of the year from November 12 to February 14 ...