The secret to cellular youth may depend on keeping the nucleolus—a condensed structure inside the nucleus of a cell—small, according to Weill Cornell Medicine investigators. The findings were ...

The secret to cellular youth may depend on keeping the nucleolus—a condensed structure inside the nucleus of a cell—small, according to Weill Cornell Medicine investigators. The findings were ...

So, nucleophosmin gets stuck in the nucleolus, and consequently ... since condensates usually rely on fluid dynamics to achieve their function, with solidification often associated with a disease ...

This leads to ribosome production arrest and a potentially alternative way p14 ARF elicits its tumor suppressor function. “Upon overexpression, p14 ARF can go to the nucleolus and block ...

Kriwacki's investigations into p14 ARF function began when the protein, upon increased expression, was found to localize to the nucleolus. Through interaction with nucleophosmin, a protein ...