A total of 803 patients were assigned to undergo left atrial appendage closure, and 797 to receive anticoagulant therapy. The mean (±SD) age of the patients was 69.6±7.7 years, 34.1% of the ...

Mineralocorticoid receptor antagonists have been shown to reduce mortality in patients after myocardial infarction with congestive heart failure. Whether routine use of spironolactone is ...

A data sharing statement provided by the authors is available with the full text of this article at NEJM.org. Supported by the Canadian Institutes of Health Research, the Population Health ...

In this phase 2 dose-finding study, we evaluated the safety and efficacy of oral infigratinib in children with achondroplasia between the ages of 3 and 11 years. A total of 72 children were ...

Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, often fatal disease. Nexiguran ziclumeran (nex-z) is an investigational therapy based on CRISPR-Cas9 (clustered regularly ...

Patients with ventricular tachycardia and ischemic cardiomyopathy are at high risk for adverse outcomes. Catheter ablation is commonly used when antiarrhythmic drugs do not suppress ventricular ...

No new safety signals were identified. A data sharing statement provided by the authors is available with the full text of this article at NEJM.org. Supported by Eli Lilly. Disclosure forms ...

Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 ...

A data sharing statement provided by the authors is available with the full text of this article at NEJM.org. Supported by Amgen. Disclosure forms provided by the authors are available with the ...

S1A in the Supplementary Appendix, available with the full text of this letter at NEJM.org). KP.2 was a JN.1 progeny that appeared, but it was later outcompeted by KP.3, with both sublineages ...

A 44-year-old woman presented to the primary care clinic with a 2-year history of shortness of breath with minimal exertion, cough productive of clear sputum, generalized fatigue, and an ...

This article was published on November 16, 2024, at NEJM.org. A data sharing statement provided by the authors is available with the full text of this article at NEJM.org. Supported by grants ...