Contrary to prevailing wisdom, the tubercular granuloma may facilitate, rather than contain, the spread of infection by Mycobacterium tuberculosis.

Citation: Volkman HE, Clay H, Beery D, Change JCW, Sherman DR, et al (2004) Tuberculous granuloma formation is enhanced by a Mycobacterium virulence determinant. PLoS Biol 2 (11): e367.

TB is an infection of Mycobacterium tuberculosis (MTB). This bacterium usually first infects the lungs after airborne transmission. It is encased in a granuloma, a small area of inflammation, and ...

This creates “caves” that trap Mycobacterium tuberculosis, known as granulomas. “[Granulomas] change over time, but they’re independent. So the environment that the bacteria are in in one granuloma ...

Granulomas — immune cell aggregates formed in response to chronic inflammatory stimuli such as Mycobacterium spp. infection — contain a range of macrophage morphologies, including polyploid ...

Multiscale Model of Mycobacterium tuberculosis Infection Maps Metabolite and Gene Perturbations to Granuloma Sterilization Predictions. Infection and Immunity , 2016; 84 (5): 1650 DOI: 10.1128/IAI ...

In 1942 this mycobacterium was found to be causing tuberculosis in freshwater platyfish in Mexico. Despite this, it was not recognised as a cause of human disease until 1951 when it was isolated in ...

Since approximately 70,000 years ago human pathogen Mycobacterium tuberculosis has been a major cause of high mortality rates in human population ... Granuloma’s cellular compositions are infected and ...

A granuloma is a cluster of white blood cells and other tissues that are generally not cancerous. They tend to develop in the lungs, on the head, or on the skin. Granulomas often go away on their own.

Citation: Volkman HE, Clay H, Beery D, Change JCW, Sherman DR, et al (2004) Tuberculous granuloma formation is enhanced by a Mycobacterium virulence determinant. PLoS Biol 2 (11): e367. RELATED TOPICS ...