Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that progresses without symptoms and is associated ...
Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system. Nature Materials , 2025; DOI: 10.1038/s41563-024-02114-5 Cite This Page : ...
This study investigates the role of macrophage lipid metabolism in the intracellular growth of Mycobacterium tuberculosis. By using a CRISPR-Cas9 gene-editing approach, the authors knocked out key ...
Lipid abnormalities play a critical role in ... LDL particles in excess infiltrate the artery and are retained in the intima. Macrophage uptake of modified LDL particles leads to cell accumulation ...
Age-Related Impairments in Immune Cell Efferocytosis and Autophagy Hinder Atherosclerosis Regression
Aged macrophages exhibit impaired lipid droplet clearance and reduced autophagy and efferocytosis, key processes essential for resolving atherosclerotic plaques. Quantitative proteomics reveal ...
One type of immune cell residing in nerves, a pro-inflammatory macrophage, began producing chemokines. These signaling molecules recruited a second population of circulating macrophages ...
Wu used a tamoxifen-inducible transgene to selectively deplete Fit2 in CX3CR1-positive brain macrophages, including microglia. By 6 months, lipid staining revealed that microglia in these mice had 30 ...
Laboratoire de Biologie et Modélisation de la Cellule, CNRS, UMR 5239, Inserm, U1293, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon, France Centre ...
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