This study investigates the role of macrophage lipid metabolism in the intracellular growth of Mycobacterium tuberculosis. By using a CRISPR-Cas9 gene-editing approach, the authors knocked out key ...

Aged macrophages exhibit impaired lipid droplet clearance and reduced autophagy and efferocytosis, key processes essential for resolving atherosclerotic plaques. Quantitative proteomics reveal ...

Figure 1 - figure supplement 2 Lipid droplet formation and fatty acid oxidation in PLIN2-/-and CPT2-/-macrophages. (A) Phenotypic characterization of lipid droplet biogenesis in PLIN2-/-macrophages.

Lipid droplet; IL-1β, interleukin-1β; Lyso, lysosome; TNF-α, tumor necrosis factor alpha; TREM2, triggering receptor expressed on myeloid cells-2. 2.3 Activating TREM2 signaling promotes cholesterol ...

Methods: Flow cytometry confirmed the expression of CD14, CD68, CD80, and CD86 markers in these macrophages. Following morphological ... a formvar-coated copper grid was gently placed on the droplet ...

A new review published in Genes & Diseases highlights macrophage-targeted therapy as a promising frontier in cardiac regeneration and myocardial repair.

One type of immune cell residing in nerves, a pro-inflammatory macrophage, began producing chemokines. These signaling molecules recruited a second population of circulating macrophages ...

"Driven by a keen interest in lipid droplet functions in aging and disease, we initiated this fruitful collaboration to harness cutting-edge SRS technology for studying lipid metabolism in ...

Lipid abnormalities play a critical role in ... LDL particles in excess infiltrate the artery and are retained in the intima. Macrophage uptake of modified LDL particles leads to cell accumulation ...

As a result, oxidized LDL is continuously taken up via these receptors, loading the macrophages with cholesterol. The lipid-engorged macrophages have a foamy appearance and are called 'foam cells ...