The ketogenic diet and the antibiotic 6-diazo-5-oxo-L-norleucine—first characterized in 1956 and referred to as DON—offer a non-toxic therapeutic strategy that could be used to manage the deadly brain ...

Once protein synthesis is excessive or misfolded protein becomes aggregated, which eventually overwhelms the capacity of the endoplasmic reticulum (ER), a state named ER stress would be reached. ER ...

With a strategy that makes use of palladium activation of both C–I and vicinal C–H bonds of diaryliodonium salts, an unprecedented approach in diarylation of coumarins was reported. As such, a wide ...