RT-PCR analysis revealed significant upregulation of genes related to hypoxia and cellular stress (Hif1a, FGf2, Atf6), mitochondrial biogenesis (mtDNA, Tfam, mt-COI, mt-COII), mitochondrial stress ...

Triple-negative breast cancer (TNBC) is the subtype of breast cancer that is the hardest to treat. TNBC patients account for more than 20,000 cases of this condition annually in the U.S. alone.

The authors provide useful data to support the existence of a regulatory pathway starting with SPI1-driven ZFP36L1 expression, that goes on to downregulate HDAC3 expression at the transcript level, ...

Background: Esophageal cancer (EC) is a major health issue, ranking seventh in incidence and sixth in mortality worldwide. Despite advancements in multidisciplinary treatment approaches, the 5-year ...

Studies of such regions have revealed unusually high levels of hypoxia inducible factor HIF1A—a proatherogenic factor that, despite its name, can also be induced by disturbed blood flow. Pirri and ...

This is evidenced by the increased content of Hif1a and CCR7 proteins compared to the other group. It is the first time such results have been obtained. "The differences found indicate that rats ...

We believe it will have a significant impact on our understanding of cavefish adaptation in particular and adaptation to low oxygen environments in general. The present investigation shows that ...