Isolation of Potential Liver Stem/Progenitor Cells A unique, specific marker for LSCs in the adult liver has not yet been assigned, and because these cells are not under constant renewal, unlike ...

"We achieved a prominent growth of hiPSC-derived liver organoids driven by hepatoblast expansion through the careful recapitulation of molecular events governed by extrinsic factors observed in ...

“ We achieved a prominent growth of hiPSC-derived liver organoids driven by hepatoblast expansion through the careful recapitulation of molecular events governed by extrinsic factors observed in ...

To explore the underlying mechanisms, the team performed single-cell RNA sequencing analysis, which revealed that IL1α influences hepatoblast expansion through the SAA1-TLR2-CCL20-CCR6 signaling ...

In this valuable study, Seidel et al. identify and characterize a novel subset of hepatocellular carcinoma patient-derived xenograft models defined by active Jagged 1-Notch2 signaling and a ...

Research on hepatic stem cells has entered a new era of controversy, excitement, and great expectations. Although adult liver stem cells have not yet been isolated, an enormous repopulating ...

First, we show that intrahepatic ALGS-like pericellular fibrosis is recapitulated in Jag1Ndr/Ndr mice. Combining single-cell transcriptomics and flow cytometry, we identify dysregulation of maturing ...

Using this device, on-chip differentiation of Human HepaRG-hepatoblast (HepaRG-HB) to HepaRG-Hepatocytes (HepaRG-HC) has been studied in terms of self-organization capabilities, bile canaliculi ...

Forward programming of human pluripotent stem cells with a combination of four transcription factors allows the production of functional hepatocytes.

A hepatoblast is the precursor in the fetus of a hepatocyte, or fully formed liver cell, and it is very similar in various ways to intestinal epithelial cells—the protective cells that line the ...

These results suggest that although acute Regorafenib treatment of hepatoblast-like cells initially creates a Wnt/β-catenin pathway-mediated increase in epithelial and stemness related markers, ...