In this Thought Leader article., Ian Johnston from Cytiva discusses challenges related to process development, scaling technology, regulatory approvals, and GMP guidelines.

Endocytosis allows eukaryotic cells to remove signaling receptors ... from where cargo is either recycled back to the plasma membrane or sorted into the endo-lysosomal pathway for degradation.

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed—for instance in case ...

Clathrin functions in receptor-mediated endocytosis at the plasma membrane when associated with ... In mammalian cells, transient expression of GFP-tagged clathrin light chain A resulted in ...

These membranes, composed of flexible lipid bilayers, can reshape and remodel themselves during processes like cell movement, division, and molecular trafficking. Until now, it was commonly assumed ...

Research shows mitochondria form distinct subpopulations under nutrient stress, revealing survival mechanisms in cancer cells ...

Here, we report the role of FCHO2 in Nedd4L-mediated ENaC endocytosis and show that FCHO2 BAR domain-generated membrane curvature induces the recruitment and activation of Nedd4L. αβγENaC-HeLa cells ...

This study presents a valuable finding on the molecular mechanisms that govern GABAergic inhibitory synapse function. The authors propose that Endophilin A1 serves as a novel regulator of GABAergic ...

Ding, B. , Wu, Y. , Zhang, Y. and Li, Y. (2024) CXCL10 Induces Lytic Reactivation of EBV through EXTL 1. Advances in ...

Red blood cells are disc-shaped cells with no nucleus. They are very small but their flattened shape gives a relatively large surface area which allows rapid diffusion of oxygen.