"We should be happy we have them, or we would not exist.” Here's what enzymes are, what they do and how you'll know if you ...

The replisome is a large protein complex that carries out DNA replication, starting at the replication origin. It contains several enzymatic activities, such as helicase, primase and DNA ...

Mitosis is the complex process in which duplicated chromosomes are condensed, segregated with the help of the mitotic spindle, and packaged in to daughter cell nuclei. Mitosis occurs in five ...

Linking together of DNA strands by DNA ligases is essential for DNA replication and repair. Since many therapies used to treat cancer act by causing DNA damage, there is growing interest in the ...

If measured from beginning to end, the DNA in our cells is too long to fit into the cell's nucleus, explaining why it must be ...

Glucose levels influence physiology and adaptation rates under replication stress, yet core adaptive mutations remain ...

He and a colleague proved a theory advanced by the Nobel Prize winners James Watson and Francis Crick, who discovered DNA’s ...

Creating genomes from DNA is hugely important for managing threatened species—understanding their past and how they have ...

New imaging tools reveal how within an hour of infection, the virus begins to alter our chromosomes to kick-start its own replication.

Franklin W. Stahl, an American molecular biologist whose landmark 1957-58 experiment with colleague Matthew Meselson revealed ...

The Annual Ligase Targeting Drug Development Summit, now in its 4th year, will unite 80+ ligase experts dedicated to tackling ligase bottlenecks through data-driven presentations, technical ...

It follows a previous report showing that the Werner syndrome protein WRN and its interacting protein WRNIP1 are indispensable for translesion DNA synthesis (TLS) by Y-family DNA polymerases (Pols).