23 Anti-CD3 monoclonal antibodies might tolerize pathogenic lymphocytes via modulation of the CD3–T-cell receptor complex, induction of clonal anergy and/or induction of regulatory T cells.

Expert Rev Clin Immunol. 2012;8(1):73-80. Advancing age is associated with loss of tolerance and increased reactivity to self. There is an increase in autoantibodies, such as rheumatoid factor and ...

Lymphocyte homeostasis requires a balance between lymphocyte proliferation induced by antigen-receptor stimulation and co-stimulation, and lymphocyte death, induced by pro-apoptotic signals from ...

The neurotrophic factor Neuritin can moderate T-cell tolerance and immunity through both regulatory T (Treg) and effector T cells, promoting Treg cell expansion and suppression while dampening ...

Glioblastoma (GBM) is a highly malignant tumor of the central nervous system that remains intractable despite advancements in current tumor treatment modalities, including immunotherapy. In recent ...