Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

Three-dimensional (3D) cancer models have emerged as pivotal tools in oncology research, offering a more accurate representation of tumor biology compared ...

The collaboration aims to enable researchers to easily adapt workflows to their applications while improving efficiency and ...

In evaluation of cell viability and apoptosis, spatial heterogeneity is quantified for cancerous cells cultured in 3-D in vitro cell-based assays under the impact of anti-cancer agents. In 48-h ...

A research team has uncovered a novel molecular pathway linking oxidative stress to cell death in pig ovarian follicles, shedding light on potential ...

A newly identified long noncoding RNA (lncRNA), named lnc2300, plays a protective role in ovarian granulosa cells but is sharply downregulated under ...

And Propidum Iodide (PI), CCK-8 (Cell counting kit-8) assay and flow cytometry were used to study cell electroporation, examine survival cells and detect cell apoptosis respectively so that we can ...

In this GEN panel discussion, three experts in cell and gene therapy development will share lessons and strategies learned from designing, validating, and scaling potency assays for both ...

To assay apoptosis in vitro, endothelial cells were grown to confluence on 8-mm gelatinized coverslips and were incubated overnight with 10 nM TSP-1 alone or in the presence of 10 μM PD98059 (an ...