The β-blocker atenolol is used widely as a first-line treatment for hypertension and as a reference drug in clinical trials. Prompted by a finding that the angiotensin-receptor blocker losartan ...

of sodium chloride per day. The cardiac output fell in 6 of the 7 patients after chlorothiazide. In Case 5 there was a 5 per cent increase in cardiac output. The average decrease in cardiac output ...

Case 1. Mrs. A.A., a 61-year-old obese woman, who was under treatment for hypertensive cardiovascular disease and was receiving hydrochlorothiazide, . . . From the Department of Dermatology and ...

Although switching is usually safe and well tolerated, physician judgment concerning individual patient requirements must be maintained. The dose of the first- or second-generation β blocker that ...