Karl-Anthony Towns likely is the player the Knicks can least do without, especially with Mitchell Robinson still unable to practice.

Donte DiVincenzo, a Knicks hero of last season’s playoffs, has been ruled out of Friday’s MSG return because of a sprained toe, the Timberwolves announced. It’ll represent the durable DiVincenzo’s first DNP of the season for the T’wolves and puts a damper on an anticipated matchup between offseason trade partners.

The Knicks' Karl-Anthony Towns (thumb) is questionable for Friday's game against the Timberwolves, who will be without starter Donte DiVincenzo (toe).

Karl-Anthony Towns of the Knicks has a bone chip in his right thumb, but is expected to try to play through the injury.

DiVincenzo is undoubtedly bummed to miss Friday's game against his old team. It would've been his first regular season game at MSG since being traded from the Knicks to the Wolves along with Julius Randle in late September.

Knicks center Karl-Anthony Towns is questionable to face his former team Friday with a sprained right thumb, while Minnesota’s Donte DiVincenzo will miss his return to Madison Square Garden with a toe injury.

The Cavaliers are coming off a 20-point loss at Oklahoma City on Thursday that left the teams tied for the best record in the NBA at 34-6. Cleveland trailed by as many as 42 points in the game and G Donovan Mitchell had a season-low eight points.