Tumour heterogeneity describes differences between tumours of the same type in different patients, and between cancer cells within a tumour. Both can lead to different responses to therapy.

The selective advantage for the establishment and, more interestingly, the maintenance of heterogeneity in tumors is unclear. Our results indicate that tumors benefit collectively from protecting ...

Cancer research is a rapidly evolving field, with a focus on understanding the complex mechanisms underlying tumor biology.

A clinical trial has shown promising results in treating brain tumours in children using an immune-cell therapy known as ...

We need to be able to kill the cancer cells but not the normal cells. Sometimes that window is so narrow that we don't have ...

Dr Marco Bezzi's group uses genome editing technologies, mouse models, organoid cultures and mass cytometry-based single cell approaches to experimentally model the cancer ecosystem and to investigate ...

Researchers advance CAR T cell therapy for solid tumors by innovating ways to overcome the unique barriers of solid tumor ...

A new study identifies key genetic vulnerabilities in glioblastoma stem cells, revealing subtype-specific dependencies that ...

Multiple myeloma "is very heterogeneous," Haertle explains. "The same tumor can contain many different genetic alterations, ...

The challenges in CTC detection, including limited quantity, technical impediments, and cellular heterogeneity, call for ...