Owing to its small, monomeric structure and high diffusibility, IgG is the most abundant type of immunoglobulin in the extracellular fluid. Its ability to bind Fc receptors on phagocytic or other ...

Figure 1: The domain structures of IgE and IgG. Figure 3: The structure of the FcεRI α-chain and its complex with IgE. The short (N-terminal) intracellular sequence of CD23 exists in two splice ...

Here, we discuss strategies to select the best therapeutic antigen targets, to optimize the structure of IgG antibodies and to design related or new structures with additional functions.