Disruption of apical–basal polarity proteins facilitates rewiring of oncogene and tumor suppressor signaling pathways to deregulate proliferation, apoptosis, invasion and metastasis.

Epithelial cells, which line the surfaces of blood vessels and organs, possess a feature called apicobasal polarity that enables them to distinguish between their exterior and interior environment by ...

Using a molecular cellular compass, individual cells in complex organisms know which way is up or down, in epithelial cells known as apical-basal polarity. Determining the orientation is essential ...