Notch–Jagged and Annexin II interactions also play a role in adhesion of tumor cells to osteoblasts. Interactions providing DTCs with a foothold also support their mitogenic activity.

The paper, by Shinya Yamamoto at Baylor College of Medicine in Houston, Texas, and colleagues was titled, "A Mutation in EGF Repeat-8 of Notch Discriminates Between Serrate/Jagged and Delta Family ...