A new study by University of Bath scientists has highlighted two new potential families of drug molecules that could open the ...

When Mycobacterium tuberculosis enters a human cell, the presence of its DNA and a molecule that it makes called c-di-AMP alert the cell to the bacteria's presence. The human cell responds by creating ...

Tuberculosis virulence factor identified, ... Sintim and colleagues tested their hypothesis by creating a mutant of Mycobacterium tuberculosis that lacked the CdnP protein and tested it in a mouse ...

The human pathogen Mycobacterium tuberculosis uses a protein secretion system called ESX-1 to export virulence factors that neutralize host defences. ESX-1 is known to be critical for virulence in ...

Researchers were studying the bacteria in question, Mycobacterium tuberculosis, ... The feedback allows the bacteria to maintain a finely-tuned level of virulence.

Restoration of genes lost during the original attenuation of the commonly used BCG tuberculosis vaccine enhances the ability of a recombinant strain to protect against Mycobacterium tuberculosis.

Tuberculosis is a chronic bacterial disease caused by the infective agent Mycobacterium tuberculosis.In 2014, 9.6 million cases of tuberculosis and 1.5 million deaths were recorded throughout the ...

Bacille Calmette-Guérin revaccination shows no efficacy in preventing sustained Mycobacterium tuberculosis infection compared with placebo in adolescents in a phase 2b study.

Tuberculosis is an infectious disease caused by a bacterium called Mycobacterium tuberculosis (Mtb), ... Stewart T. Cole. Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence ...

The Rv0455c protein of Mycobacterium tuberculosis, previously annotated as a protein of unknown function, has been shown to function in siderophore secretion. Siderophores acquire iron from the ...

The authors observed that M. marinum mutants with a disabling mutation at the ESX1 locus, a chromosomal region critical to the virulence of M. tuberculosis, 2 are able to infect phagocytes but do ...

Cite this article. Tiwari, P., Arora, G., Singh, M. et al. Correction: Corrigendum: MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence ...