When lipid biologist Usha Acharya at the National Cancer Institute (NCI) tinkered with lipid breakdown pathways in Drosophila ...

This occurs through signalling via the Toll-like receptor TLR4 and through endoplasmic reticulum stress promoted by intracellular lipid accumulation. It results in the production of reactive ...

elegans with neuronal mitochondrial stress and observed an extended lifespan, enhanced pathogen resistance, and reduced lipid ...

Importantly, the gene is linked to hepatocyte lipid accumulation and, by extension, to conditions like hepatic steatosis. Its loss-of-function mutation, rs72613567, results in a truncated, inactive ...

Ferroptosis offers new strategies to combat treatment resistance in digestive tract cancers, enhancing the efficacy of ...

That tau dysregulation derails lipid droplets “provides novel mechanistic insight into how accumulation of human tau in the brain may lead to neurodegeneration in AD,” he wrote. Nancy Bonini of the ...