LDL receptor activity and uptake of LDL regulate plasma LDL concentration by several mechanisms, including decreasing the synthesis of hydroxy-3-methyglutaryl coenzyme A (HMG-CoA) reductase (which ...

With an almost total lack of LDL receptors for uptake LDL, these patients have extremely high LDL cholesterol (typically >400 ...

The prevalence of type 2 diabetes, along with related conditions, such as metabolic syndrome and obesity, has increased ...

Their findings suggest that drugs targeting this nuclear receptor may be able to lower LDL (bad) cholesterol in an animal model. Thomas Burris, Ph.D., chair of pharmacology and physiology at Saint ...

While studying the uptake of low-density lipoproteins (LDLs) by skin fibroblasts, they observed that LDL internalization was mediated by a specific receptor present in the surface of the cells.

Liver X receptor beta (LXRβ) shows potential in reducing depression and anxiety by improving neurogenesis, reducing ...

Mutations in LXRα lead to liver cholesterol buildup, hepatitis, and fibrosis in individuals on a Western diet, highlighting the ... and reduced very low-density lipoprotein (VLDL) triglyceride ...

[8] No single PS-specific receptor appears to be involved ... Incubation of oxPL with labeled LDL resulted in enhanced uptake of the latter, which was perhaps related to electrostatic charge ...

“It seems to work by upregulating LDL-receptors [low-density lipoprotein cholesterol ... “Essentially, it improves insulin sensitivity and promotes glucose uptake from the blood,” Singh says. And, yes ...

The findings are significant for the liver research community and others interested in the gut-liver axis. (A) AOAH cleaves the two piggyback fatty acyl chains from the lipid A moiety, inactivating ...

Despite uncertainty around who will sit in The White House in January and what ramifications they may bring, the industry’s ...