The interaction between CD2 and CD58 is critical for forming the immunological synapse, which is pivotal in immune cell activation and adhesion, as well as signaling in both immune and target cells.

Researchers combined advanced imaging techniques with a computational method to probe how immune cells interact with each other, revealing that the interactions between immune cells in the vicinity of ...

How might the immune system take advantage of the B cell synapse to optimize the effectiveness of encounters between B cells and soluble toxin or circulating viruses? The answer may lie ...

When a B cell encounters membrane-bound antigen, signalling through the B-cell receptor (BCR) induces cytoskeletal reorganization and morphological changes that lead to the formation of an ...

Discover five T cell engager companies that have emerged in recent times, as this class of therapeutics is set to take off.

The CD2-CD58 axis is associated with the regulation of autoimmune diseases, immune evasion of tumors, antiviral responses, and immune rejection, and targeted therapies for this have been developed.

CTLs and NK cells kill by forming a stereotyped interface with their targets, known as a cytolytic immunological synapse, into which they secrete a mixture of toxic perforin and granzymes. Our ...

Indapta Therapeutics, Inc., a privately held clinical stage biotechnology company developing next-generation differentiated cell therapies for the treatment of cancer and autoimmune diseases, today ...

The team developed a method dubbed Computational Immune Synapse Analysis (CISA) which detects not only which cells within a tissue contact each other physically, but also whether key molecules are ...

The brain, traditionally considered an immune-privileged organ due to the blood-brain barrier (BBB), has its own sophisticated immune defense system. Microglia, the primary immune cells of the central ...

However, neither approach tells scientists whether the proteins are on the cell’s surface at a synapse, contributing to interactions with other cells. “There can be a number of reasons that an immune ...