The formation of macrophage foam cells, which are characteristic of atherosclerotic lesions, correlates with suppression of inflammatory genes.

Macrophage foam cells, a major component of the atherosclerotic lesion, have vital roles in the development of atherosclerosis. Lipoautophagy, a type of autophagy characterized by selective ...

The persistence of cholesterol-engorged macrophages (foam cells) in the artery wall fuels the development of atherosclerosis. However, the mechanism that regulates the formation of macrophage foam ...

CD8+ T cells accumulate in atherosclerotic plaques. LMU researchers identify a crucial signaling pathway—with therapeutic ...

For the first time, scientists have demonstrated that a type of immune cell expresses a protein that promotes the buildup of fatty material in arteries.

In the center of an atheroma, foam cells and extracellular lipid droplets form a core region, which is surrounded by a cap of smooth-muscle cells and a collagen-rich matrix.

Macrophages differentiate into foam cells during the formation and progression of atherosclerosis. Understanding the process of this change during the progression of atherosclerotic plaques will ...

Most obviously, some fraction of the foam cells die, releasing lipids. For this reason, pathologists denote the region under the cap as the lipid or necrotic core.

For a long time, macrophages and foam cells were considered the principal agents in the formation of plaques. More recent studies, however, have focused on other immune system cells, CD8+ T cells ...

These macrophages were the most transcriptionally primed to launch an exosomal assault. To investigate the effects of foam cell exosomes, researchers generated them in a dish. They cultured bone ...

CD8+ T cells accumulate in atherosclerotic plaques. Researchers identify a crucial signaling pathway -- with therapeutic potential.

Macrophage foam cells produce cytokines that stimulate smooth muscle cell infiltration, which in turn promotes extracellular matrix production and fibrosis.