The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

In this study, the researchers report that VGLL3 can be recruited to DSBs in a PARylation- and chromodomain helicase ...

ATP-dependent RNA ligases join 3’-OH and 5’-PO 4 RNA termini via three nucleotidyl transfer steps similar to those of DNA ligases: (Step 1) ligase reacts with ATP to form a covalent ...

Replicative sliding clamp loading is critical for DNA replication and repair ... dependent DNA ligation of shortmer fragments by DNA ligases, which is compatible with numerous chemical ...

During DNA replication, special enzymes move up along the DNA ladder, unzipping the molecule as it moves along. New nucleotides move in to each side of the unzipped ladder. The bases on these ...

New research shows that DNA replication in early mouse embryos doesn't follow the expected patterns seen in older cells. A ...

Genetic analysis of cavity crud from two famed man-eating lions suggests the method could re-create diets of predators that lived thousands of years ago.

Telomere shortening and DNA damage play crucial roles in aging, a multifaceted biological phenomenon characterized by a ...

A research group is the first in the world to succeed in constructing artificial cell nuclei by injecting purified DNA ...

Rosalee Hellberg, an associate professor in Chapman University's Food Science Program, and her research team have made a ...

Scientists have sequenced DNA from 3,600-year-old cheese, the oldest in the archaeological record. The intact cheese was ...