Researchers have discovered that the prevalent cytosine-to-thymine mutations in cancer are mainly due to mistakes in DNA replication rather than spontaneous reactions. The study identifies the role of ...

Researchers have discovered a plausible evolutionary setting in which nucleic acids—the fundamental genetic building blocks ...

The breakthrough research was conducted by scientists at the Indian Association for the Cultivation of Science (IACS), ...

Scientists have identified a promising new target for cancer treatment by activating a DNA repair enzyme called TDP1, ...

The enzymes that handle DNA molecules are often called "polymerases," but the -ase suffix denotes an enzyme. When not undergoing replication, DNA molecules float freely within the cytoplasm of a cell.

A centromere is a specialized location in the DNA that functions as the control center of cell division and is maintained, ...

The fundamental building blocks of genetic material may have replicated on their own, potentially giving rise to life on ...

New research shows that DNA replication in early mouse embryos doesn't follow the expected patterns seen in older cells. A ...

Telomere shortening and DNA damage play crucial roles in aging, a multifaceted biological phenomenon characterized by a ...

Jennifer A. Surtees, PhD, professor of biochemistry and associate dean of undergraduate education and STEM outreach in the Jacobs School, is principal investigator on a $2.45 million NIH grant funding ...

Errors in non-coding regions are detected during cell renewal, which requires the creation of a new copy of the genome each time, via the process of DNA replication. However, cell renewal does not ...

This important work shows how a simple geophysical setting of gas flow over a narrow channel of water can create a physical environment that leads to the isothermal replication of nucleic acids. The ...