The genetic code normally requires Watson–Crick base pairing at the first two positions of the codon–anticodon helix, and tolerates certain specific mismatches at the third (wobble) position.

The ribosome-bound codon could then base pair with a particular tRNA that carried the amino acid specified by the codon (Figure 2). Nirenberg and Leder thus synthesized many short mRNAs with known ...

The universal genetic code is made up of several codons or triplet bases. The standard code has evolved over time to minimize coding errors. There are a total of 64 codons in the genetic code ...

A codon is a sequence of three bases which join up to create a unit of DNA information. One codon directs one building block known as an “amino-acid” in a protein.

If the anticodon does not match the codon, base pairing cannot happen and the tRNA is rejected. Then, the ribosome moves one codon forward making space for a new tRNA-amino acid complex to enter.

Genetic Code Supports Targeted Insertion of Two Amino Acids by One Codon Science, 323 (5911), 259-261 DOI: 10.1126/science.1164748 Subscribe to the feed Related Topics ...