Induction of T-cell clonal anergy involves serial activation of transcription factors, including NFAT and Egr2/3. However, downstream effector mechanisms of these transcription factors are not ...

Engagement of the T cell receptor (TCR) in the absence of CD28 costimulation can result in a long-term hyporesponsive state called 'clonal anergy' 1. Anergic T cells have defective production of ...

Anergy occurs under several different circumstances, suggesting that T cells are poised to become anergic--presumably a protective response that helps limit immune reactions and prevent responses ...

Phase I study of intranodal direct injection of adenovirus encoding recombinant CD40-ligand (Ad-ISF35) in patients with chronic lymphocytic leukemia This is an ASCO Meeting Abstract from the 2009 ASCO ...

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele ...

Study: Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis. Image Credit: BioFoto / Shutterstock ...