The interaction between CD2 and CD58 is critical for forming the immunological synapse, which is pivotal in immune cell activation and adhesion, as well as signaling in both immune and target cells.

The CD2-CD58 axis is associated with the regulation of autoimmune diseases, immune evasion of tumors, antiviral responses, and immune rejection, and targeted therapies for this have been developed.

“Her keen understanding of cancer immunotherapy development and the overall treatment landscape will be invaluable as we seek to fully exploit the potential of trispecific T cell engagers with ...