History has shown us that divisional matchups could end up closer than expected, but you couldn't tell that from many of the Week 16 NFL odds. Bills vs. Patriots has Buffalo favored by 14 points in the largest of the Week 16 NFL lines and one of the biggest NFL spreads of the season.

Our first lookahead line best bet for Week 17 will be the New Orleans Saints on the moneyline. I'm still getting the hang of gaining positive EV on an underdog. We've done it a couple of times. However, primarily, we've hunted betting favorites, and they've usually been very public plays.

The Cleveland Browns (3-11) are already out of playoff contention, but they could make the Cincinnati Bengals (6-8) join them when they visit their divisional foe. Nothing went right for Cleveland when the Kansas City Chiefs came to town.