The San Francisco 49ers are going to have a fourth different starting running back this season according to a report from ESPN’s Adam Schefter. Running back Isaac Guerendo suffered a

The 49ers will have to start their fourth different running back this Sunday against the Miami Dolphins. That's because rookie running back Isaac Guerendo is likely to miss Sunday's game with a hamstring injury he suffered this past Thursday night.

San Francisco 49ers running back Isaac Guerendo is unlikely to play in Sunday's game against the host Miami Dolphins, ESPN reported Thursday. Guerendo is nursing a foot injury sustained in the 49ers' 12-6 loss to the Los Angeles Rams last Thursday.