The body horror film, directed by Coralie Fargeat, is nominated for five categories at the 2025 Academy Awards, including Best Actress for Moore and Best Picture

Dennis Quaid, who starred in the 2025 Oscar-nominated film “The Substance” with Demi Moore and Margaret Qualley, is confident that Moore will win big at the Academy Awards on Sunday.

The Substance took theaters by storm, but the body horror film starring Demi Moore is not for the weak. Some viewers might prefer to watch it at home so they can take a breath and a walk around the block after witnessing French filmmaker Coralie Fargeat’s confrontational and explicit imagery.

Demi Moore is up for an Oscar for Best Actress this Sunday, and her career journey over the decades been quite a ride! Access Hollywood looks back at her Hollywood beginnings on "General Hospital" and her many memorable movie performances,

It's rare for a movie like "The Substance" to break into the Oscars race. Written and directed by French filmmaker Coralie Fargeat, the film is an intense, satirical and violent body horror thriller about insecurity and the pressures of the unrealistic beauty standards that society forces onto women both when they are young and when they are older.