Jayuya is a town and municipality of Puerto Rico located in the mountainous center region of the island, north of Ponce; east of Utua…Jayuya is a town and municipality of Puerto Rico located in the mountainous center region of the island, north of Ponce; east of Utuado; and west of Ciales. Jayuya is spread over 10 barrios and Jayuya Pueblo. It is the principal city of the Jayuya Micropolitan Statistical Area.