Vendôme is a subprefecture of the department of Loir-et-Cher, France. It is also the department's third-biggest commune with 15,856 inhabitants…Vendôme is a subprefecture of the department of Loir-et-Cher, France. It is also the department's third-biggest commune with 15,856 inhabitants. It is one of the main towns along the river Loir. The river divides itself at the entrance of Vendôme, intersecting it into numerous different arms. The town has a rich medieval history and many historical monuments.