Syracuse is a city in Morgan County, Missouri, United States. The population was 151 at the 2020 census. In the middle of the 19th cen…Syracuse is a city in Morgan County, Missouri, United States. The population was 151 at the 2020 census. In the middle of the 19th century, the city was the western terminus of the Pacific Railway that reached 108 miles from St. Louis. The current mayor of Syracuse is Duane A. Doyle.
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