Cherokee Lake, also known as Cherokee Reservoir, is an artificial reservoir in the U.S. state of Tennessee formed by the impoundment of the Holston River behind Cherokee Dam. The reservoir has a surface area of about 28,780 acres, a flood-storage capacity of 749,406 acre-feet, and nearly 400 miles of shoreline. In a normal year, the lake water level fl…Cherokee Lake, also known as Cherokee Reservoir, is an artificial reservoir in the U.S. state of Tennessee formed by the impoundment of the Holston River behind Cherokee Dam. The reservoir has a surface area of about 28,780 acres, a flood-storage capacity of 749,406 acre-feet, and nearly 400 miles of shoreline. In a normal year, the lake water level fluctuates over a range of about 27 feet.